Back when I was reading slush for PodCastle, one of the things that would get me to perk up was when a writer would introduce a clear character motivation within the first page. This didn't have to be anything major. In fact, it didn't necessarily have to be the focus of the story. I just wanted to feel a sense of purpose from the get-go. I hated reading a story and not having a clear understand of why I was reading.
hink of all the hours you spent typing away at your keyboard, and now you need to just delete some of it. I know it sounds stupid, but this could be the metaphorical difference between life and death for your manuscript.